A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion system
Article
Published on
Journal: Journal of Applied Microbiology
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,
Journal: Journal of Applied Microbiology
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,
[키워드] administration
Analysis
antibody
Antigen
antigens
attenuated Salmonella ΔhtrA-VNP
Bacterial
caused
CD44
CD69
COVID-19 vaccine
cytometric
cytosol
delivery
effective
element
elicited
Express
expression
Flow
fluorescence microscopy
Heterologous
IgA
IgG
in vitro
increase in
Macrophage
mixed bacterial preparations.
mutant
N-protein
NTD
Oral vaccine
pathogenicity
phenotype
Plasmid
promoter
RBD
S-protein
Safe
Salmonella
SARS-CoV-2
SARS-CoV-2 antigen
SARS-CoV-2 vaccine
screened
secrete
secretion
shown
Significance
Significant
significant increase
SPI-2
strain
T-cell activation
T3SS
the vaccine
type III
Vaccine
was used
[DOI] 10.1111/jam.15720 PMC 바로가기
[DOI] 10.1111/jam.15720 PMC 바로가기